Publications

44. eIF3d and eIF3e mediate selective translational control of hypoxia that can be inhibited bysmall molecules, Purdy, S. C.; Matlin, K.; Alderman, C.; Baldwin, A.; Shrivastava, N.; Dutta, S.; Webb, K. J.; Wolin, A.; Boulton, D.; Kapali, J.; Landua, J.; Lewis, M.; Caino, C.; Old, W.; Wang, X.; Zhao, R.;Mukherjee, N.; Ford, H. L. Cell Report 2025 44, 116643. doi: 10.1016/j.celrep.2025.116643. PMID: 41364558

43. Potent synthetic lethality between PLK1 and EYA family inhibitors in tumors of the central and peripheral nervous systems, Nelson CB, Wells JK, Kesarwani E, Sobinoff AP, Fernando M, Gao J, MacKenzie KL, Poulos RC, Nawaz U, Wang X, Ford HL, Pickett HA. Genes Dev. 2026, 40, 267. doi: 10.1101/gad.353271.125. PMID: 41266088.

42. Extended structure-activity relationship studies of the [1,2,5]oxadiazolo[3,4-b]pyrazine-containing colistin adjuvants, Harris, S. L.; Dutta, S.; Liu, N.; Wollenberg, T.; Wang, X.Bioorg. Med. Chem. Lett.2025,115, 130008. https://doi.org/10.1016/j.bmcl.2024.130008. [].

41.Rational design of novel allosteric EYA2 inhibitors as potential therapeutics for multiple brain cancers, Gardner, L.; Rossi, J.;Armstrong, B.;Muse, M.;LaVeck, A.; Blevins, M.;Zhang, L.;Ford, H.; Zhao, R.;Wang, X. 𳾵ǰ.2024,e202400179. doi: 10.1002/cmdc.202400179 [].

40.Practical synthesis of isoindolines yields potent colistin potentiators for multidrug-resistantԱٴDzٱܳԲԾ, Dutta, S.; Eyolfson, S.; Zhu, Y.; Gao, Y.; Wang, X. Org. & Biomol. Chem.2024,22, 4057–4061 [].

39.A Small-Molecule Membrane Fluidizer Re-sensitizes Methicillin-ResistantStaphylococcus aureus(MRSA) toβ-Lactam Antibiotics, Podoll, J. D.; Rosen, E.; Wang, W.; Gao, Y.; Zhang, J.; Wang, X. Antimicrob. Agents Chemother. 2023,18;67(10):e0005123. doi: 10.1128/aac.00051-23[].

38. Recent Developments of Isoindole Chemistry, Weintraub, R. A.; Wang, X.Գٳ, 2023, 519[].

37. Structure-Activity Relationship Studies of [1,2,5]Oxadiazolo[3,4-b]pyrazine-ContainingPolymyxin-Selective Resistance-Modifying Agents,Somnath, D.; Liu, N.;Gao, Y.; Beck, L.;Wang, X.Bioorg. Med. Chem. Lett. 2022, 72, 128878.[].

36. Serendipitous Discovery of a Highly Active and Selective Resistance-Modifying Agent for Colistin-Resistant Gram-Negative Bacteria,Gao, Y.;Somnath, D.;Wang, X.ACS Omega 2022, 7, 12442. []

35. A Cell-Free Screen for Bacterial Membrane Disruptors Identifies Mefloquine as a Novel Antibiotic Adjuvant, Podoll, J.; Olson, J.; Wang, W.; Wang, X.Antibiotics2021, 10(3), 315. []

34. One-Pot Synthesis of Polycyclic Isoindolines Using Isoindole Umpolung,Weintraub, R. A.; He, W.;Wang, X. Tetrahedron Lett. 2020, 61, 152128. []

33. Tryptoline-BasedBenzothiazolesRe-sensitize MRSA to β-LactamAntibiotics,Wang, X.; Chen, J.; Wang, W.; Jaunaraj, A.;Wang, X.Bioorg. & Med. Chem.2019,27, 115095–115106. []

32. Identification and Characterization of a Novel Anti-inflammatory Lipid Isolated fromMycobacterium vaccae, a Soil-Derived Bacterium with Immunoregulatory and Stress Resilience Properties,Smith, D. G.; Martinelli, R.; Besra, G. S.; Illarionov, P. A.; Szatmari, I.; Brazda, P.; Allen, M. A.; Xu, W.;Wang, X.; Nagy, L.; Dowell, R. D.; Rook G. A. W.; Brunet, L. R.; Lowry, C. A.Phycopharmacology,2019,236(5),1653–1670. []

31. Enantioselective Tandem Cyclization of Alkyne-Tethered Indoles Using Cooperative Silver(I) and Chiral Phosphoric Acid Catalysis. Zhu Y,He W, Wang W, Pitsch CE, Wang X,Wang X, AngewChem,Int. Ed.2017,40, 12206–12209.

DOI: 10.1002/anie.201706694 and 10.1002/ange.201706694 []

cooperative catalysis

30. Diastereoselective Synthesis and Biological Evaluation of Enantiomerically Pure Tricyclic Indolines. He W, Griffiths BM,Wang W, Wang X, Org. Biomol. Chem., 2017;15:4241-4245.

DOI: 10.1039/C7OB00897J []

Diastereoselective synthesis of tricyclic indolines

29. Tetracyclic Indolines as aNovel Class of β-Lactam-Selective Resistance Modifying Agent for MRSA.Zhu Y, Cleaver L, Wang W, Podoll JD, Walls S, Jolly A, Wang X.EurJMedChem.2017;125:130-142.

DOI: 10.1016/j.ejmech.2016.09.034 []

tetracyclic indoline

28. Bioinspired Discovery of Chemical Reactions and Biological Probes. Griffiths B, Burl J, Wang X.Synlett. 2016;27:2039-2042.

DOI: 10.1055/s-0035-1561638[]

bioinspired discovery

27.Property-Guided Synthesis of Aza-Tricyclic Indolines: Development of Gold Catalysis En Route. Barbour PM, Wang W, Chang L, Pickard KL, Rais R, Slusher BS, Wang X. AdvSynthCatal. 2016;358:1482-1490.[Theme: Gold Catalysis: Quo Vadis?]

DOI: 10.1002/adsc.201501101 []

aza-tricyclic indoline

26. A Fluorescence Polarization Biophysical Assay for theNaegleriaDNA Hydroxylase Tet1. Marholz LJ, Wang W, Zheng Y, Wang X.ACS Med Chem Lett. 2016;7:167-171. [Theme: Epigenetics]

DOI: 10.1021/acsmedchemlett.5b00366 []

25.Gold-Catalyzed Cyclization Leads to A Bridged Tetracyclic Indolenine That Represses β-Lactam Resistance. Xu W, Wang W, Wang X. Angew Chem Int Ed. 2015;54:9546-9549; Angew Chem. 2015;127:9682-9685.

DOI: 10.1002/anie.201503736 (International)and 10.1002/ange.201503736 (German)[]

24. Novel Scaffolds of Cell-Active Histone Demethylase Inhibitors Identified from High-Throughput Screening. Wang W, Marholz LJ, Wang X. J Biomol Screen.2015;20:821-827.

DOI: 10.1177/1087057115579637[]; Featured on GMD []

23.Discovery and Initial Structure-Activity Relationships ofN-Benzyl Tricyclic Indolines as Antibacterials for Methicillin-ResistantStaphylococcus Aureus. Barbour PM, Podoll JD, Marholz LJ, Wang X. Bioorg Med Chem Lett. 2014;24:5602-5605.

DOI:10.1016/j.bmcl.2014.10.094. []

22. Development of Substrate-Selective Probes for Affinity Pulldown of Histone Demethylases. Marholz LJ, Chang L, Old WM, Wang X. ACS Chem Biol. 2015;10:129-137.

DOI: 10.1021/cb5006867 []

21.A Histone Demethylase Inhibitor, Methylstat, Inhibits Angiogenesis in vitro and in vivo. Cho Y, Kim KH, Xu W, Wang X, Kwon HJ.RSC Adv. 2014;4:38230-38233.

DOI: 10.1039/c4ra07154a []

20.Structure-Activity Relationship Studies of the Tricyclic Indoline Resistance-Modifying Agent. Chang L, Podoll JD, Wang W, Walls S,O'Rourke CP, Wang X. J Med Chem. 2014;57:3803-3817.

DOI: 10.1021/jm500146g

19. Gold Approaches to Polycyclic Indole Alkaloids. Barbour PM, Marholz LJ, Chang L, Xu W, Wang X. Chem Lett. 2014;43:572-578.

DOI: 10.1246/cl.131230[]

18. Bio-Inspired Synthesis Yields A Tricyclic Indoline That Selectively Resensitizes MRSA to β-Lactam Antibiotics. Podoll JD, Liu Y, Chang L, Walls S, Wang W, Wang X. Proc Natl Acad Sci USA. 2013;110:15573-15578.

DOI: 10.1073/pnas.1310459110;Highlighted by PNAS;Recommended by Faculty of 1000

17. Quantitative Analysis of Histone Demethylase Probes Using Fluorescence Polarization. Xu W, Podoll JD, Dong X, Tumber A, Oppermann U, Wang X. J Med Chem. 2013;56:5198-5202.

DOI: 10.1021/jm3018628;Highlighted by Nature SciBX

16. A One-Pot Three-Component Reaction for the Preparation of Highly Functionalized Tryptamines. Yeo SJ, Liu Y, Wang X. Tetrahedron.2012;68:813-818.

DOI:10.1016/j.tet.2011.11.032

15. A Selective Inhibitor and Probe of the Cellular Functions of Jumonji C Domain-Containing Histone Demethylases. Luo X,Liu Y,Kubicek S,Myllyharju J,Tumber A,Ng S,Che KH,Podoll J,Heightman TD,Oppermann U,Schreiber SL,Wang X. J Am Chem Soc. 2011;133:9451-9456.

DOI: 10.1021/ja201597b;Highlighted by Nature SciBX

14. Selective Gold(I)-Catalyzed Formation of Tetracyclic Indolines: A Single Transition State and Bifurcations Lead to Multiple Products. Noey EL, Wang X, Houk KN. J Org Chem. 2011;76:3477-83.

DOI:10.1021/jo200556f

13. Gold(I)-Catalyzed Tandem Cyclization Approach to Tetracyclic Indolines. Liu Y, Xu W, Wang X. Org Lett. 2010;12:1448-51.

DOI: 10.1021/ol100153h

12. AAK1 Identified as an Inhibitor of Neuregulin-1/ErbB4-Dependent Neurotrophic Factor Signaling Using Integrative Chemical Genomics and Proteomics. Kuai L, Ong SE, Madison JM, Wang X, Duvall JR, Lewis TA, Luce CJ, Conner SD, Pearlman DA, Wood JL, Schreiber SL, Carr SA, Scolnick EM, Haggarty SJ. Chem & Biol. 2011;18;891-906.

11. Chemical genetics identifies small-molecule modulators of neuritogenesis involving neuregulin-1/ErbB4 signaling. Kuai L, Wang X, Madison JM, Schreiber SL, Scolnick EM, Haggarty SJ. ACS Chem Neurosci. 2010;1;325-42.

10. Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of sonic hedgehog. Peng LF, Stanton BZ, Maloof N, Wang X, Schreiber SL. Bioorg Med Chem Lett. 2009;19: 6319-25.

9. Identifying the proteins to which small-molecule probes and drugs bind in cells. Ong SE, Schenone M, Margolin AA, Li X, Do K, Doud MK, Mani DR, Kuai L, Wang X, Wood JL, Tolliday NJ, Koehler AN, Marcaurelle LA, Golub TR, Gould RJ, Schreiber SL, Carr SA. Proc Natl Acad Sci U S A. 2009;106;4617-22.

8. A small molecule that binds Hedgehog and blocks its signaling in human cells. Stanton B, Peng LF, Maloof N, Nakai K, Wang X, Duffner JL, Taveras KM, Hyman JM,Lee SW, Koehler AN, Chen JK, Fox JL, Mandinova A, Schreiber SL. Nat Chem Biol. 2009;5:154-6.

7. Diversity synthesis of complex pyridines yields a probe of a neurotrophic signalling pathway. Gray BL, Wang X, Brown WC, Kuai L, Schreiber SL. Org Lett. 2008;10:2621-4.

6. Small-molecule reagents for cellular pull-down experiments. Wang X, Imber BS, Schreiber SL. Bioconjug Chem. 2008;19:585-7.

5. Synthesis of the tetracyclic core of the tetrapetalones via transannular oxidative [4+3] cyclization. Wang X, Porco JA Jr. Angew Chem Int Ed Eng. 2005;44:3067-71;Corrigendum: 2006;45:6607.

4. Total synthesis of the salicylate enamide macrolide oximidine III: application of relay ring-closing metathesis. Wang X, Bowman EJ, Bowman BJ, Porco JA Jr. Angew Chem Int Ed Eng. 2004;43:3601-5.

3. Total synthesis of the salicylate enamide macrolide oximidine II. Wang X, Porco JA Jr. J Am Chem Soc. 2003;125:6040-1.

2. Modification of C-terminal peptides to form peptide enamides: synthesis of chondriamides A and C. Wang X, Porco JA Jr. J Org Chem. 2001;66:8215-21.

1. Parallel synthesis and purification using anthracene-tagged substrates. Wang X, Parlow JJ, Porco JA Jr. Org Lett. 2000;2:3509-12.

1.Histone demethylase inhibitors and methods for using the same. Wang, Xiang; Xu, Wenqing. U.S. 8,735,622.

2.“Indoline Alkaloid Compounds,” Podoll JD; Chang L; Wang, Xiang PCT/US14/32585.

3. "Polycycilc Indoline and Indolenine Compounds," Barbour PM, Wang, Xiang PCT/US62/154,792.

4.“1,3,4,9-Tetrahydro-2H-Pyrido[3,4-B]Indole Derivative Compounds and Uses Thereof,” Zhang, Jing; Podoll, Jessica D.;Wang, Xiang.US62/719,048.

5. “Tryptoline-Based Benzothiazoles and their use as Antibiotics and Antibiotic Resistance-Modifying Agents,” Wang, Xinfeng.;Wang, Xiang. US 62/895,380.